Table 1.
Clinical characteristics
| All patients (n=42) | LGE (−) (n=17; 40.5%) | LGE (+) (n=25; 59.5%) | p Value | |
|---|---|---|---|---|
| Age at CMR | 47.57±16 | 50.29±16.58 | 45.73±15.68 | NS |
| Female | 12 (28.5) | 5 (29.4) | 7 (28) | NS |
| Hypertension | 15 (35.7) | 9 (52.9) | 6 (24) | 0.055 |
| Family history of HCM | 13 (30.9) | 4 (23.5) | 9 (36) | NS |
| Family history of sudden death | 6 (15) | 2 (11.7) | 4 (16) | NS |
| Atrial fibrillation history | 10 (23.8) | 4 (23.5) | 6 (24) | NS |
| Chest pain | 11 (26.2) | 8 (47) | 3 (12) | 0.029 |
| Syncope | 6 (14.3) | 1 (5.8) | 5 (20) | NS |
| Heart failure | 7 (16.7) | 2 (11.7) | 5 (20) | NS |
| NYHA class | NS | |||
| 1 | 30 (71.4) | 12 (70.5) | 18 (72) | |
| 2 | 10 (23.8) | 4 (23.5) | 6 (24) | |
| 3 | 2 (4.8) | 1 (5.8) | 1 (4) | |
| Mean NYHA class | 1.33±0.57 | 1.35±0.58 | 1.32±0.55 | NS |
| β-blockers | 30 (71.4) | 12 (70.5) | 18 (72) | NS |
| Calcium antagonist | 1 (2.4) | 0 (0) | 1 (4) | NS |
| Echocardiography | NS | |||
| Ejection fraction | 65±9 | 63±9 | 66±9 | NS |
| Maximum wall thickness (mm) | 18±3 | 17±3 | 18±4 | NS |
| Wall thickness >30 mm | 1 (2.4) | 0 (0) | 1 (4) | NS |
| Rest LVOTO >30 mm Hg | 1 (2.4) | 1 (5.8) | 0 (0) | NS |
| Non-sustained VT on 24H-Holter ECG | 9 (21.4) | 3 (17.6) | 6 (24) | NS |
| Abnormal BP response to exercise | 4 (9.5) | 1 (5.8) | 3 (2) | NS |
Data are presented as the mean value±SD or number (%) of subjects.
BP, blood pressure; CMR, cardiac MRI; HCM, hypertrophic cardiomyopathy; LGE, late gadolinium enhancement; LVOTO, left ventricular outflow tract obstruction; NS, not significant; NYHA, New York Heart Association.