Fig. 1.
Estrogen dependent formation of endometrial cancer in PRcre+ Ptenf/f mice. (A) The ratio of uterine weight to body weight in intact and ovariectomized E2 treated PRcre+ Ptenf/f mice (OVX E2). The results represent the mean±SEM. *P< 0.05, ***P<0.001. (B) The uterine gross morphology of intact and ovariectomized E2 treated Ptenf/f mice (OVX E2) (a, b) and PRcre+ Ptenf/f mice (c, d). (C) Estrogen (E2) treatment induces endometrial cancer development in Pten ablated mice uterus. Hematoxylin and eosin staining of intact and ovariectomized E2 treated Ptenf/f mice (OVX E2) (a, b) and PRcre+ Ptenf/f mice (c, d).