Table 2.
Atrophic gastritis and intestinal metaplasia in the antrum
| No. of subjects (%) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| Total population | Male | Female | |||||||||
|
| |||||||||||
| Control (n=224) | FDR (n=224) | P-value (OR) | Control (n=68) | FDR (n=68) | P-value (OR) | Control (n=156) | FDR (n=156) | P-value (OR) | |||
| Atrophic gastritis | IAa | 34 (15.2) | 36 (16.1) | 15 (22.1) | 11 (16.2) | 19 (12.2) | 25 (16.0) | ||||
| Absent | 123 (54.9) | 108 (48.2) | 0.50* | 37 (54.4) | 28 (41.2) | 0.009* | 86 (55.1) | 80 (51.3) | 0.87* | ||
| Present | 67 (29.9) | 80 (35.7) | 0.15** (1.36) | 16 (23.5) | 29 (42.6) | 0.034** (2.40) | 51 (32.7) | 51 (32.7) | 0.77** (1.08) | ||
| Metaplasticb | None | 13 (5.8) | 16 (7.1) | 0.82† | 3 (4.4) | 6 (8.8) | 0.039† | 10 (6.4) | 10 (6.4) | 0.97† | |
| Slight | 19 (8.5) | 31 (13.8) | 3 (4.4) | 15 (22.1) | 16 (10.3) | 16 (10.3) | |||||
| Moderate | 8 (3.6) | 8 (3.6) | 2 (2.9) | 0 (0) | 6 (3.8) | 8 (5.1) | |||||
| Marked | 2 (0.9) | 2 (0.9) | 0 (0) | 0 (0) | 2 (1.3) | 2 (1.3) | |||||
| Non-Metaplasticc | None | 110 (49.1) | 92 (41.1) | 0.75†† | 34 (50.0) | 22 (32.4) | 0.26†† | 76 (48.7) | 70 (44.9) | 0.80†† | |
| Slight | 35 (15.6) | 36 (16.1) | 9 (13.2) | 13 (19.1) | 26 (16.7) | 23 (14.7) | |||||
| Moderate | 3 (1.3) | 3 (1.3) | 2 (2.9) | 1 (1.5) | 1 (0.6) | 2 (1.3) | |||||
| Marked | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |||||
| Intestinal metaplasia | Absent | 174 (77.7) | 151 (67.4) | 0.032‡ | 56 (82.4) | 43 (63.2) | 0.043‡ | 118 (75.6) | 108 (69.2) | 0.22‡ | |
| Present | Total | 50 (22.3) | 73 (32.6) | 0.015‡‡ (1.68) | 12 (17.6) | 25 (36.8) | 0.012‡‡ (2.71) | 38 (24.4) | 48 (30.8) | 0.21‡‡ (1.38) | |
| Slight | 22 (9.8) | 43 (19.2) | 6 (8.8) | 14 (20.6) | 16 (10.3) | 29 (18.6) | |||||
| Moderate | 25 (11.1) | 28 (12.5) | 5 (7.4) | 11 (16.2) | 20 (12.8) | 17 (10.9) | |||||
| Marked | 3 (1.33) | 2 (0.9) | 1 (1.5) | 0 (0) | 2 (1.28) | 2 (1.3) | |||||
FDR, first degree relatives of gastric cancer.
Indefinite for atrophy.
Atrophic gastritis with intestinal metaplasia present.
Atrophic gastritis without intestinal metaplasia present P-values were calculated using χ2-test.
Histological grade is according to updated Sydney scoring system (0=none, 1=slight, 2=moderate, and 3=marked).
Compared histological grade of atrophic gastritis regardless of presence of intestinal metaplasia;
compared histological presence of atrophic gastritis regardless of presence of intestinal metaplasia;
compared histological grade of metaplastic atrophic gastritis;
compared histological grade of non-metaplastic atrophic gastritis;
compared histological grade of intestinal metaplasia;
compared histological presence of intestinal metaplasia.