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. 2014 Oct;51(4):516–525. doi: 10.1165/rcmb.2013-0237OC

Figure 4.

Figure 4.

Multicilin (MCI) expression is inhibited by submersion in a γ-secretase–dependent manner. Expression of (A) MCI and (B) FOXJ1 mRNAs during NHBE differentiation at an ALI in air (21% O2; orange), submerged (0.5 ml; blue), or submerged (0.5 ml) with 10 μM DAPT (green). MCI and FOXJ1 mRNAs are normalized to the housekeeping gene, B2M. The graphs show that expression of MCI and FOXJ1 mRNAs is inhibited by submersion, but that inhibition is overcome by adding DAPT (n = 3). Data shown are means (± SEM).