Table 1.
Measurements of Inflammation in Room Air–exposed versus Hyperoxia-exposed Neonatal Mice*
| Readout | RA (n) | O2 (n) | P Value |
|---|---|---|---|
| BALF | |||
| Total cell counts | 1.98 × 106 ± 8.4 × 104 (6) | 2.94 × 106 ± 2.1 × 104 (4) | 0.001 |
| Protein concentration, μl/μl | 0.08 ± 0.01 (6) | 0.11 ± 0.02 (6) | NS |
| Cytokines (lung tissue lysates), pg/ml | |||
| IL-1β | 29.6 ± 4.4 (6) | 44.9 ± 6.6 (6) | 0.08 |
| IL-6 | 9.2 ± 1.1 (6) | 17.5 ± 1.7 (6) | 0.002 |
| TNF-α | 2.4 ± 0.3 (6) | 4.0 ± 0.6 (6) | 0.045 |
| IL-10 | 3.8 ± 1.0 (6) | 8.3 ± 1.3 (6) | 0.019 |
| TGF-β | 764 ± 80 (6) | 1169 ± 163 (6) | 0.05 |
Definition of abbreviations: BALF, bronchoalveolar lavage fluid; O2, hyperoxia; NS, not significant; RA, room air.
*
Four days of RA versus O2 exposure followed by 14 d RA recovery.