Table 2.

mRNA Gene Expression by Real-Time PCR in Room Air–exposed versus Hyperoxia-exposed Neonatal Mice^*

Gene	RA (n = 5)	O2 (n = 4)	P Value
Nrf2-mediated antioxidant genes (FC)
Ho-1	1.06 ± 0.17	↑ 5.48 ± 1.12	0.003
Gclc	1.08 ± 0.24	↑ 3.22 ± 0.38	0.002
Nqo-1	1.017 ± 0.10	↑ 9.09 ± 0.90	<0.001
SOD antioxidant genes (FC)
SOD1	1.039 ± 0.15	↑ 3.96 ± 0.98	<0.001
SOD2	1.01 ± 0.06	↑ 1.86 ± 0.03	<0.001
SOD3	1.01 ± 0.07	↓ 0.36 ± 0.06	<0.001

Definition of abbreviations: FC, fold change; Gclc, glutamate-cysteine ligase catalytic subunit; Ho-1, heme oxygenase-1; Nqo-1, NAD(P)H dehydrogenase [quinine]-1; Nrf2, nuclear factor erythroid 2; O2, hyperoxia; RA, room air; SOD, superoxide dismutase.

^*Five days RA versus O2 exposure followed by 14-d RA recovery.