TABLE II.

Recommendations for supportive care in newly diagnosed or suspected acute promyelocytic leukemia (apl)

	Supportive care	Implementation	Target
1	Frequent, aggressive transfusions	Cryoprecipitate	Fibrinogen levels should be greater than 1.5 g/L
		Platelets	Platelet counts should be at least 30×109/L
		Fresh-frozen plasma
2	Therapy with atra	Should be started immediately	Should be administered in divided doses
			Purpose is to treat coagulopathy and to initiate induction
3	Frequent monitoring	Immediate	Every 6 hours

atra = all-trans-retinoic acid.