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Proposed model of the mechanisms involved in PAF-mediated EGFR transactivation in SKOV-3 ovarian cancer cells. In response to PAF, activated PAFR triggers the EGFR/ERK transactivation pathway via PLCβ, intracellular Ca2+, Src and the ADAM-mediated release of EGFR ligand HB-EGF. PAF also triggers the PKC pathway to couple to ERK phosphorylation.
