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Morphology of hepatocellular carcinomas with LAMA2 mutations. Hematoxylin and eosin (H&E)-stained sections of HCC with LAMA2 mutation (upper panels, 9193, 3206A7 009) show poorly differentiated neoplastic hepatocytes with cellular and nuclear pleomorphism, mitotic figures (arrow) and moderate to abundant stroma (asterisks). H&E-stained sections of HCC with wild-type LAMA2 generally have more uniform, well-differentiated neoplastic cell morphology (lower panels). Scale bar is 20 μm.
