Table 4.
Median levels of IFN-γ (pg/ml), minimum and maximum values (in brackets) elicited in no TB infected individuals, subjects with LTBI and active TB patients by the antigens, when tested after long-term stimulation.
| Antigen | No TB infection | TB Infection | Active TB | p-value | |||
|---|---|---|---|---|---|---|---|
| n | Median | n | Median | n | Median | ||
| CONTROL | |||||||
| PHA | 94 | 1136.0 (189.8, 6443.0) | 293 | 1013.9 (296.5, 12135.5) | 102 | 854.3 (0.0, 4026.3) | 0.000 |
| PPD | 89 | 13.5 (0.0, 925.5) | 275 | 59.5 (0.0, 2246.0) | 99 | 60.0 (0.0, 1681.2) | 0.000 |
| TB10.4 | 94 | 1.6 (0.0, 115.0) | 288 | 3.2 (0.0, 1154.0) | 100 | 1.5 (0.0, 675.0) | 0.004 |
| ESAT6/CFP10 | 93 | 86.0 (0.0, 2818.5) | 280 | 163.5 (0.0, 6440.0) | 100 | 29.7 (0.0, 3966.0) | 0.000 |
| DosR | |||||||
| Rv0570c | 8 | 0.0 (0.0, 4.5) | 19 | 0.0 (0.0, 5.0) | 5 | 1.5 (0.5, 5.5) | 0.012 |
| Rv1733 | 4 | 345.3 (178.5, 2766.5) | 20 | 356.5 (3.5, 2150.0) | 10 | 7.3 (1.0, 394.5) | 0.010 |
| REACTIVATION | |||||||
| Rv1471 | 3 | 2.0 (1.5, 38.5) | 15 | 1.0 (0.0, 25.5) | 8 | 10 (0.0, 1.5) | 0.028 |
| Rpf, OTHER STRESS-INDUCED | |||||||
| Rv0244 | 8 | 17.8 (5.0, 50.0) | 24 | 7.3 (0.0, 63.5) | 8 | 0.3 (0.0, 4.5) | 0.005 |
| Rv2389 | 7 | 148.5 (12.0, 257.0) | 16 | 135.8 (1.5, 610.5) | 5 | 22.5 (5.0, 59.5) | 0.046 |
| IVE-TB | |||||||
| Rv0847 | 7 | 6.5 (2.5, 182.5) | 21 | 3.5 (0.0, 298.5) | 9 | 1.0 (0.0, 111.0) | 0.011 |
| Rv2558 | 4 | 1.0 (0.0, 2.5) | 17 | 0.0 (0.0, 2.0) | 9 | 0.5 (0.0, 6.5) | 0.038 |
| Rv2642 | 3 | 23.5 (16.5, 315.0) | 15 | 33.5 (1.5, 191.0) | 8 | 1.0 (0.0, 3.5) | 0.002 |
N indicates the number of subjects in each group. Data were analyzed by Kruskal Wallis test for the comparison of no TB infection, TB infection, and active TB groups of patients. Only significant differences (p < 0.05) were included.