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. 2014 Sep 18;16(5):427. doi: 10.1186/s13075-014-0427-y

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© Nagai et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of gene expression and histology between the normal bevacizumab and normal groups (experiment 1). (A) Synovial gene expression. (B) Subchondral bone gene expression. (C) Articular cartilage gene expression. Gene expression data are expressed as mean ± SD (n = 6 knees). The y-axis is defined as follows: 2^–ΔCT normal B target gene/2^–ΔCT normal target gene. *P <0.05 by the Mann-Whitney U-test. (D) Representative articular cartilage histology for the normal group (left side) and normal bevacizumab group (right side) stained with Safranin O. (E) Representative synovial histology for the normal group (left side) and normal bevacizumab group (right side) stained with H&E. (F) Higher magnifications of the image in (E) stained with H&E. Histology data were obtained from six knees per group. Bars = 1 mm (E); bars = 300 μm (D, F).