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. 2014 Sep 27;8:112. doi: 10.1186/s12918-014-0112-4

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© Lakatos et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The signaling and transcriptional network considered to regulate mouse ES cell maintenance. (a) Full model. Green, red and blue arrows represent transcriptional activation, repression and translation, respectively. Black arrows represent complex formation, and various multi-step processes: (i) FGF secretion resulting in an effective autocrine ligand concentration and (ii) activation of the MAPK. (b) Schematic representation of the autocrine feedback loop. The suggested model acts as a noisy negative feedback regulator which includes a signal amplifier and delay.