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. 2014 Sep 27;8:112. doi: 10.1186/s12918-014-0112-4

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© Lakatos et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The KLF4-ESRRB module as an amplifier. We consider an autocatalytic regulation of KLF4, and cooperative positive regulation from NANOG (a). Keeping [NANOG] at various pre-determined values, we obtained the steady state concentrations and promoter activity of KLF4 and ESRRB. The relationship between these values and [NANOG] is strongly non-linear, reflecting the autoregulation and cooperative binding with NANOG. The solid line represent fitted Hill curves with n=2.3±0.2 and n=6.2±0.4 for KLF4 and ESRRB, respectively (b, c). Concentrations are presented in the units of nM.