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. 2014 Sep 27;8:112. doi: 10.1186/s12918-014-0112-4

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© Lakatos et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effects of modulating the transcriptional regulation of Nanog . Steady state protein concentrations are plotted for various values of C _Nanog,OS, the binding energy among RNAP II, the OCT4/SOX2 dimer and the Nanog locus. If the binding energy is set by ERK activity through the feedback (14), the system evolves into a steady state (gray symbols) which depends on parameter a, the strength of the feedback.