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. 2014 Oct;39(10):695-697, 715.

Table 1.

Common Acquired Causes of Hyperuricemia2

Cause Increased Urate Production Decreased Renal Excretion of Urate
Metabolic/endrocrine

  • Excess purine from diet

  • Ethanol

  • Fructose consumption

  • Dehydration

  • Lactic acidosis

  • Ketosis

  • Hypothyroidism

  • Hyperparathyroidism
Hematological/renal

  • Myeloproliferative disorders

  • Polycythemia

  • Lymphoproliferative disorders

  • Hypertension

  • Polycystic kidney disease

  • Chronic renal failure
Drugs

  • Ethanol

  • Cytotoxic drugs

  • Vitamin B12 (treatment of pernicious anemia)

  • Ethanol

  • Cyclosporine (Sandimmune)

  • Thiazide diuretics

  • Loop diuretics

  • Ethambutol (Myambutol)

  • Pyrazinamide

  • Aspirin (low-dose)

  • Levodopa (Larodopa)

  • Nicotinic acid (Niacin)
Miscellaneous

  • Obesity

  • Psoriasis

  • Hypertriglyceridemia

  • Obesity

  • Sarcoidosis

  • Toxemia of pregnancy

  • Chronic lead intoxication