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. 2014 Sep 29;9:4581–4595. doi: 10.2147/IJN.S69115

Figure 2.

Figure 2

The synthesis of F-CONH-PEG-NH-Chol (folate-CONH-PEG-NH-Cholesterol).

Notes: Folate was linked to PEG-bis-amine by an amide bond first. Then cholesterol–OTs was reacted with folate-CONH-PEG-NH2 to form folate-CONH-PEG-NH-Chol by C-N bond connection.

Abbreviation: cholesterol-OTs, cholesterol-p-toluenesulfonate.