Figure 2.
The synthesis of F-CONH-PEG-NH-Chol (folate-CONH-PEG-NH-Cholesterol).
Notes: Folate was linked to PEG-bis-amine by an amide bond first. Then cholesterol–OTs was reacted with folate-CONH-PEG-NH2 to form folate-CONH-PEG-NH-Chol by C-N bond connection.
Abbreviation: cholesterol-OTs, cholesterol-p-toluenesulfonate.