Figure 5.

5-LO activity is required for dendritic cell activation into the inflammation site. The in vivo surface markers of DCs from the WT (white bars) or 5-LO^−/− (black bars) infected mice at the 6th wpi were determined by flow cytometry. The dot plots represent the frequency of CD40 (a), CD86 (b), and MHC-II (c) in the CD11c^high population. All analyses were performed on CD11b⁺CD11c^high gated cells. The data are expressed as the mean ± SEM, N = 5-6. *P < 0.05 compared to the WT group.