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NADH produced during glycolysis and the tricarboxylic acid (TCA) cycle is consumed by the electron transfer chain. NADPH generated by the catalysis of glucose-6-phosphate dehydrogenase (G6PD) is utilized to reduce oxidized glutathione (GSSG) by glutathione reductase (GR) or oxidized thioredoxin (Trx) by thioredoxin reductase (TR).
