Appendix Table 2. Quality Assessment of Diagnostic Accuracy Studies 2 Results for Included Studies.

Author, Year (Reference)	Risk of Bias				Applicability Concerns
	Patient Selection	Index Test	Reference Standard	Flow and Timing	Patient Selection	Index Test	Reference Standard
Sohn et al, 2005 (14)	Unclear risk	Unclear risk	Unclear risk	Low risk	High risk	Low risk	Low risk
Levi et al, 2011 (15)	Low risk	Low risk	High risk	High risk	Low risk	Low risk	Low risk
Allison et al, 1996 (31)	High risk	Low risk	High risk	High risk	Low risk	Low risk	Low risk
Allison et al, 2007 (32)	High risk	Low risk	High risk	High risk	High risk	Low risk	Low risk
Levi et al, 2007 (33)	Low risk	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Cheng et al, 2002 (34)	High risk	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Morikawa et al, 2005 (35)	Low risk	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Nakama et al, 1999 (36)	Unclear risk	Unclear risk	Unclear risk	Low risk	High risk	Low risk	Low risk
Nakama et al, 1996 (37)	Unclear risk	Unclear risk	High risk	High risk	High risk	Low risk	Low risk
Launoy et al, 2005 (38)	Low risk	Low risk	High risk	High risk	Low risk	Low risk	Low risk
Itoh et al, 1996 (39)	Low risk	Low risk	High risk	High risk	Low risk	Low risk	Low risk
Nakazato et al, 2006 (40)	Low risk	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Park et al, 2010 (41)	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
de Wijkerslooth et al, 2012 (42)	Low risk	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Parra-Blanco et al, 2010 (43)	Low risk	Low risk	High risk	High risk	Low risk	Low risk	Low risk
Chiu et al, 2013 (44)	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Chiang et al, 2011 (45)	Low risk	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Brenner and Tao, 2013 (46)	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Brenner and Tao, 2013 (46)	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk