Table 2. Subgroup Analysis Based on FIT Samples, FIT Cutoff Value, FIT Brand, and Reference Standard.
| Variable | Studies, n |
Sensitivity (95% CI) |
I2* | Between- Study Variance in Logit Sensitivity |
Specificity (95% CI) |
I2* | Between- Study Variance in Logit Specificity |
Positive LR (95% CI) |
I2* | Negative LR (95% CI) |
I2* |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FIT samples | |||||||||||
|
| |||||||||||
| 1-sample | 13 | 0.78 (0.65–0.87) | 75.9 | 1.00 | 0.95 (0.93–0.96) | 98.9 | 0.33 | 14.2 (11.6–17.5) | 91.6 | 0.24 (0.15–0.38) | 84.8 |
|
| |||||||||||
| 2-sample | 4 | 0.77 (0.59–0.89) | 61.1 | 0.43 | 0.93 (0.90–0.95) | 98.7 | 0.17 | 11.2 (6.5–19.5) | 89.0 | 0.25 (0.13–0.49) | 73.9 |
|
| |||||||||||
| 3-sample | 6 | 0.80 (0.66–0.89) | 5.2 | 0.07 | 0.93 (0.89–0.95) | 97.7 | 0.30 | 11.3 (7.4–17.5) | 88.4 | 0.21 (0.12–0.38) | 0 |
|
| |||||||||||
| FIT cutoff value for a positive test result | |||||||||||
| <20 μg/g | 11 | 0.86 (0.75–0.92) | 56.4 | 0.60 | 0.91 (0.89–0.93) | 98.6 | 0.16 | 9.8 (7.7–12.5) | 93.3 | 0.16 (0.09–0.28) | 62.2 |
|
| |||||||||||
| 20–50 μg/g | 6 | 0.63 (0.43–0.79) | 56.2 | 0.60 | 0.96 (0.94–0.97) | 94.7 | 0.25 | 16.6 (12.9–21.4) | 0 | 0.39 (0.24–0.63) | 73.1 |
|
| |||||||||||
| >50 μg/g | 4 | 0.67 (0.59–0.74) | 33.2 | 0.00 | 0.96 (0.94–0.98) | 99.2 | 0.24 | 18.7 (11.7–29.8) | 92.2 | 0.34 (0.27–0.43) | 37.6 |
| FIT brand | |||||||||||
|
| |||||||||||
| OC-Micro/Sensor | 5 | 0.86 (0.68–0.95) | 0 | 0.28 | 0.91 (0.87–0.94) | 95.5 | 0.21 | 9.7 (6.8–13.9) | 54.4 | 0.16 (0.06–0.38) | 0 |
|
| |||||||||||
| OC-Light | 4 | 0.93 (0.83–0.97) | 26.6 | 0.07 | 0.91 (0.88–0.92) | 95.9 | 0.06 | 9.9 (8.0–12.2) | 85.7 | 0.08 (0.03–0.20) | 9.99 |
| Reference standard | |||||||||||
|
| |||||||||||
| Colonoscopy | 12 | 0.71 (0.58–0.81) | 64.4 | 0.66 | 0.94 (0.91–0.96) | 98.8 | 0.47 | 11.4 (8.6–15.2) | 82.1 | 0.31 (0.21–0.45) | 74.0 |
|
| |||||||||||
| 2-y follow-up† | 7 | 0.87 (0.75–0.93) | 39.0 | 0.39 | 0.94 (0.92–0.96) | 97.1 | 0.18 | 15.2 (11.6–20.0) | 85.4 | 0.14 (0.07–0.27) | 29.5 |
FIT = fecal immunochemical test; LR = likelihood ratio.
*
Inconsistency index minus the measure of heterogeneity.
†
At least a 2-y longitudinal follow-up with medical records or cancer registry.