Table 3. Sensitivity Analysis: Summary Estimates of Subgroups After Removing Discontinued FITs.

Variable	Studies, n	Sensitivity (95% CI)	I2*	Between-Study Variance in Logit Sensitivity	Specificity (95% CI)	I2*	Between-Study Variance in Logit Specificity	Positive LR (95% CI)	I2*	Negative LR (95% CI)	I2*
FIT sample
1-sample	11	0.78 (0.65–0.87)	58.1	0.63	0.94 (0.92–0.95)	98.2	0.17	12.8 (10.8–15.1)	85.9	0.23 (0.14–0.38)	49.8
2-sample†	4	0.77 (0.59–0.89)	61.1	0.43	0.93 (0.90–0.95)	98.7	0.17	11.2 (6.5–19.5)	89.0	0.25 (0.13–0.49)	73.9
3-sample	6	0.80 (0.66–0.89)	5.2	0.07	0.93 (0.89–0.95)	97.7	0.30	11.3 (7.4–17.5)	88.4	0.21 (0.12–0.38)	0
FIT cutoff value for a positive test result
<20 μg/g	9	0.89 (0.80–0.95)	26.4	0.32	0.91 (0.89–0.93)	94.9	0.12	10.2 (8.3–12.3)	75.2	0.12 (0.06–0.22)	14.5
20–50 μg/g	5	0.70 (0.55–0.81)	0	0.10	0.95 (0.95–0.96)	82.0	0.03	15.3 (12.5–18.8)	0	0.32 (0.21–0.49)	0
>50 μg/g	4	0.67 (0.59–0.74)	33.2	0.00	0.96 (0.94–0.98)	99.2	0.24	18.7 (11.7–29.8)	92.2	0.34 (0.27–0.43)	37.6
FIT brand
OC-Micro/Sensor	5	0.86 (0.68–0.95)	0	0.28	0.91 (0.87–0.94)	95.5	0.21	9.7 (6.8–13.9)	54.4	0.16 (0.06–0.38)	0
OC-Light	4	0.93 (0.83–0.97)	26.6	0.07	0.91 (0.88–0.92)	95.9	0.06	9.9 (8.0–12.2)	85.7	0.08 (0.03–0.20)	9.99
Reference standard
Colonoscopy	10	0.77 (0.65–0.86)	45.7	0.60	0.93 (0.91–0.95)	98.2	0.21	11.6 (9.6–14.0)	78.9	0.25 (0.16–0.39)	27.1
2-y follow-up‡	5	0.91 (0.78–0.97)	0	0.52	0.94 (0.91–0.96)	97.9	0.25	15.6 (10.8–22.7)	88.0	0.09 (0.03–0.25)	0

FIT = fecal immunochemical test; LR = likelihood ratio.

^*Inconsistency index minus the measure of heterogeneity.

^†Unable to do a sensitivity analysis because of the lack of data sets/studies.

^‡At least a 2-y longitudinal follow-up with medical records or cancer registry.