Figure 1.

Monocyte subsets (a) and FCγ-R expression profile of monocytes (b) in the peripheral blood of congenital toxoplasmosis infants (TOXO) and noninfected controls (NI). Congenital toxoplasmosis was further categorized according to the clinical ocular status, referred to as no retinochoroidal lesions (NRL), active retinochoroidal lesions (ARL), active/cicatricial retinochoroidal lesions (ACRL), and cicatricial retinochoroidal lesions (CRL). The results are expressed as scatter plots of individual values and the medians of absolute cell counts/mm³ (left side) or in box-plot format (right side), where the box stretches from the lower hinge (25th percentile) to the upper hinge (75th percentile), and the middle half represents the median of the distribution as a line across the box. Significant differences are highlighted by connecting lines, and P values are shown in the figure. (c) Representative histograms illustrating the downregulation of CD32 (top panels) and the upregulation of CD64 (bottom panels) on circulating monocytes from infants with congenital toxoplasmosis (black) compared to noninfected controls (white). The dashed lines were set to highlight the shift in the histogram distribution toward lower or higher FCγ-R expression by monocytes.