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. 2014 Jun 3;23(21):5597–5614. doi: 10.1093/hmg/ddu274

Figure 2.

Figure 2.

Peroxidasin during eye development. (A and B) Immunofluorescence studies showed weak Pxdn expression in the lens vesicle at E11.5. (C–F) At E13.5, it is highly expressed in the anterior lens epithelium, in the posterior lens fiber cells, in the inner limiting membrane (C and D) and in some mesenchymal cells in the vitreous (E and F, arrow); (E–F) are a close-up of (C) and (D). (G–J) At E17.5, Pxdn is mainly expressed in the lens epithelial cells, in the posterior part of the lens (G and H) and in inner neuroblastic layer (I and J). However, Pxdn is still expressed in the lens and in the inner neuroblastic layer and the expression pattern is similar to the wild-type eyes at E17.5 (K–N). Negative controls (without primary antibody) were shown in the most right panel. DC, developing cornea; L, lens; R, retina; LE, lens epithelium; LV, lens vesicle; INBL, inner neuroblast layer; ONBL, outer neuroblast layer; VC, vitreous cavity. Green: peroxidasin; blue: DAPI. Scale bar: 50 µm.