Table 2.
Summary of eye phenotypes in KTA048 homozygous mutants at P17–P21
| Phenotype | Disorganized corneal stromal cells | Smaller eyes and lenses | Disorganized lens matrix and lens rupturea | Lens tissue in AC and VC | Lens-corneal adhesion | Iris-corneal adhesion | Iris and ciliary body hypoplasia | Vitreous tissue | Retinal folds and rosette | Retinal tract |
|---|---|---|---|---|---|---|---|---|---|---|
| Number (9 eyes) | 9/9 | 9/9 | 9/9 | 9/9 | 9/9 | 9/9 | 9/9 | 2/9 | 8/9 | 8/9 |
| Percentage | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 22.2 | 88.9 | 88.9 |
These data are based on the histological observation of eyes. AC, anterior chamber; VC, vitreous cavity.
aShort for the loss of structural identity of the lens capsule.