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Hypothetical pathways of the DB7 fusion gene. Cell metabolism is tightly coupled with protein synthesis. Reduction of NADH oxidoreductase activity may alter production of ATP and NAD+ which can trigger at least two known pathways (AMPK and Sirtuin) to down-regulate rRNA transcription and protein translation. AMPK, AMP-activated protein kinase; TSC1 and TSC2, tuberous sclerosis complex 1 and 2; mTOR, mammalian target of rapamycin.
