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Flow diagram. iNO: inhaled nitric oxide, N2: nitrogen (placebo). Groups 1 (iNO) and 3 (placebo) received iNO 80 ppm or placebo (N2) throughout the entire operation. Group 2 (piNO) has a break in NO administration during the period of activated tourniquet and administration of NO restarts approximately 2 minutes before the tourniquet release.
