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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Genet Epidemiol. 2014 Sep 12;38(7):638–651. doi: 10.1002/gepi.21852

Table 1.

P-values for gene by longitudinal BMI interaction

SNP Positionb Gene BMIc
(14–
19
yrs.)		 BMI
(20–
29
yrs.)		 BMI
(30–
39
yrs.)		 BMI
(40–
49
yrs.)		 BMI
(50–
59
yrs.)		 BMId
(Bonf.
)		 BMIe
(MinP;
boot)		 ave
BMIf 		max
BMIf 		auc
BMIf 		PC1g PC95g BMIh
(Score
)		 FLRi
(Score
)		 FLRi
(SSU
)
rs505922 chr9: 136149229 ABO .63a .28 .87 .82 .67 1.0 .83 .84 .66 .80 .79 .53 .42 .61 .77
rs1558902 chr16: 53803574 FTO .11 .14 .72 .33 .99 .55 .46 .40 .97 .38 .35 .38 .06 .39 .36
rs8050136 chr16: 53816275 FTO .04 .02 .04 .03 .12 .12 .14 .03 .09 .03 .03 .11 .17 .10 .02
rs1202940 chr1: 199905828 NR5A 2 .69 .98 .15 .09 .19 .44 .38 .24 .12 .23 .26 .38 .23 .39 .18
rs3790844 chr1: 200007432 NR5A 2 .62 .73 .35 .09 .11 .43 .34 .21 .12 .22 .24 .41 .63 .43 .23
rs3790843 chr1: 200010824 NR5A 2 .58 .96 .22 .13 .21 .65 .54 .26 .17 .27 .29 .61 .70 .65 .32
rs401681 chr5: 1322087 CLPT M1L-TERT .42 .99 .94 .95 .98 1.0 .94 .92 .83 .97 .92 .64 .88 .63 1.0
a

All p-values were adjusted for age and gender.

b

chromosome number and position (human reference genome hg19).

c

Gene by age-specific BMI interaction by Model (1).

d

Adjusted minimum p-value (minP) for age-specific interactions based on the Bonferroni procedure.

e

minP based on parametric bootstrap.

f

aveBM: average BMI; maxBMI: maximum BMI; aucBMI: area under the BMI curve.

g

PC1: the first PC from multivariate PCA; PC95: leading PCs explaining at least 95% of total variation.

h

Score test p-value for gene by longitudinal BMI interaction via multiple logistic regression Model (2).

i

Functional logistic regression (FLR)-based score test and Sum of Squared score (SSU) test.