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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Circulation. 2014 Aug 14;130(15):1245–1253. doi: 10.1161/CIRCULATIONAHA.114.011590

Figure 2.

Figure 2

Multivariable hazard ratios of plasma phospholipid linoleic acid with risk of total mortality, evaluated by restricted cubic splines from Cox models adjusted for age, gender, race, enrollment site, education, smoking status, prevalent diabetes, atrial fibrillation, and hypertension, leisure-time physical activity, body mass index, waist circumference, alcohol use, and plasma phospholipid long-chain n-3 PUFA levels. The solid lines and shaded areas represent the central risk estimates and 95% CIs, respectively, relative to the reference level (12.5th percentile). The dotted vertical lines correspond to the 10th, 25th, 50th, 75th, and 90th percentiles of linoleic acid levels. A significant inverse association was evident (P=0.005), with little evidence for nonlinearity (P nonlinearity=0.16).