Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2014 Jul;23(4):352–360. doi: 10.1097/01.mnh.0000447016.21228.e0

Figure 1.

Figure 1

Three-month-old renal tubule-specific CaSR-deficient mice (rtCasr−/−) compared to littermate controls. A. Urinary calcium to creatinine ratio (Uca/crea) in rtCasr−/− mice demonstrate relative hypocalciuria under high calcium diet (1.5% calcium chloride drinking water); 0.25±0.02 vs. 0.56±0.2. B. Relative quantitation (RQ) of claudin14 (CLDN14), a negative regulator of paracellular ion transport in the thick ascending limb (TAL), displays ~80% decreased expression levels in rtCasr−/− from whole kidney RNA; 1.2±0.18 vs. 4.8±1.7. C. On the contrary, expression level of claudin16 (CLDN16), which facilitates paracellular cation transport in the TAL (together with claudin19), is slightly but significantly increased; 2.3±0.2 vs. 1.4±0.8. Data were analyzed with non-parametric test.