Table 1.
Global, CD43-, and CD45-specific glycosylation during T cell development
| Thymus Cell type: | Double negative | Double positive | CD4 or CD8 single positive |
|---|---|---|---|
| Global O-glycans: | Sialylated core 1 | Asialo-core 1; core 2 | Sialylated core 1 |
| Global N-glycans: | High mannose; hybrid | High mannose; hybrid | α2,6-sialylated complex |
| CD43 O-glycans: | Core 1 | Core 1; core 2 | Core 1 |
| CD45 isoform: | RA, RBC, RB | RO | RB, RBC |
| CD45 O-glycans: | nda | Sialo-core 1; core 2 | nd |
| CD45 N-glycans: | High mannose; hybrid | High mannose; hybrid | α2,6-sialylated complex |
| Periphery Cell type: | Naive CD4+ or CD8+ | Activated CD8+ | Activated CD4+ | Th1 | Th2 |
|---|---|---|---|---|---|
| Global O-glycans: | Sialylated core 1 | Asialo-core 1; core 2 | Asialo-core 1; core 2 | Asialo-core 1; core 2 | Sialylated core 1 |
| Global N-glycans: | α2,6-sialylated complex | Complex | Complex | Complex | α2,6-sialylated complex |
| CD43 O-glycans: | Core 1 | Core 1; core 2 | Core 1; core 2 | Core 1; core 2 | nd |
| CD45 isoform: | RB | RO | RO | RO | RO |
| CD45 O-glycans: | Sialylated core 1 | Asialo-core 1 | asialo-core 1 | nd | nd |
| CD45 N-glycans: | α2,6-sialylated complex | Complex | Complex | Complex | nd |
a
Nd: not determined