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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Aug 31;21(10):864–870. doi: 10.1038/nsmb.2880

Figure 1.

Figure 1

Structure and binding interface of human SA2–Scc1. (a) Cartoon diagram of the crystal structure of human SA2 in complex with the SA2-binding region of Scc1, with SA2 colored blue and Scc1 colored pink. The N-terminal helical domain and the 17 HEAT repeats (R1-R17) of SA2 are labeled. The N- and C-termini of SA2 and Scc1 are indicated. The four major contact sites (I–IV) between SA2 and Scc1 are boxed in dashed lines. A schematic drawing of the cohesin architecture is shown in lower right corner. (b–e) Zoomed in views of sites I–IV, with SA2 and Scc1 residues in yellow and gray sticks, respectively. Scc1 residues are labeled in red.