Table 5. Demographic, serological and virological characteristics of HBV/D (D1-IndD4) samples.

HBV/D subgenotype	D1 [n = 4]	D2 [n = 14]	D3 [n = 36]	IndD4 [n = 13]	p-value [D1, D2, D3 and IndD4]	p-value [D1, D2, D3 group vs IndD4]
Age [years], mean±SD	41.00±12.70	32.77±13.31	37.86±12.29	30.31±9.49
ALT [IU/l], Median, Range	59.75 [21.00 – 72.50]	39.75 [30.00– 96.10]	47.05 [15.60– 145.90]	38.00 [18.00– 62.00]	0.3852$	0.1593#
AST [IU/l], Median, Range	38.20 [34.00 – 46.20]	49.00 [32.10– 72.00]	49.85 [17.70– 110.0]	32.00 [10.00– 52.00]	0.0069*$	0.0005*#
HBV DNA [IU/ml], Median, Range	2.41×102 [14.21 – 1.7×108]	9.15×106 [3.4×105 – 1.7×108]	3.09×103 [79 – 6.9×104]	8.6×101 [20– 7.99×102]	0.0002*$	0.0222* #
HBeAg negativity [%]	75	57.14	100	100

SD, standard deviation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; IU, international unit; #Mann-Whitney test p-value; $One-way ANOVA p value; *p-value <0.05 was considered significant.