Table 3.
Nuclear and cytoplasmic Ep-ICD expression in invasive ductal carcinoma (IDC) and correlation with clinicopathological parameters
| Clinicopathological parameters | Total cases (n = 180) | Ep-ICD Nuclear | p-value | Odd’s ratio (95% C.I.) | Ep-ICD Cytoplasm | p-value | Odd’s ratio (95% C.I.) | ||
|---|---|---|---|---|---|---|---|---|---|
| N | (%) | n | (%) | ||||||
| IDC cases | 75 | 42 | - | - | 145 | 81 | - | - | |
| Age | |||||||||
| < 59 years | 88 | 39 | 44.3 | 74 | 84.1 | ||||
| ≥ 59 years | 92 | 36 | 39.1 | 0.480 | 0.80 (0.45–1.45) | 71 | 77.2 | 0.241 | 0.64(0.30–1.36) |
| Tumor Size a | |||||||||
| ≤2 cm | 81 | 35 | 43.2 | 69 | 85.2 | ||||
| > 2 cm | 96 | 37 | 38.5 | 0.529 | 0.82 (0.45–1.50) | 73 | 76.0 | 0.128 | 0.55(0.25–1.20) |
| T-stage | |||||||||
| T 1 + T 2 | 171 | 71 | 41.5 | 138 | 80.7 | ||||
| T 3 + T 4 | 9 | 4 | 44.4 | 0.862 | 1.13 (0.30–4.34) | 7 | 77.8 | 0.829 | 0.84(0.17–4.22) |
| Nodal Status | |||||||||
| N x+0 | 123 | 58 | 47.2 | 99 | 80.5 | ||||
| N 1–3 | 57 | 17 | 29.8 | 0.028 | 0.48 (0.24–0.98) | 46 | 80.7 | 0.973 | 1.02(0.45–2.24) |
| Stage | |||||||||
| I + II | 159 | 68 | 42.8 | 130 | 81.8 | ||||
| III + IV | 21 | 7 | 33.3 | 0.410 | 0.67 (0.26–1.74) | 15 | 71.4 | 0.261 | 0.56(0.20–1.56) |
| Grade b | |||||||||
| I + II | 108 | 53 | 49.1 | 90 | 83.3 | ||||
| III | 65 | 20 | 30.8 | 0.018 | 0.46 (0.24–0.89) | 48 | 73.8 | 0.132 | 0.57(0.27–1.20) |
| Clinical Recurrence | |||||||||
| No | 155 | 50 | 32.3 | 121 | 78.1 | ||||
| Yes | 25 | 25 | 100 | <0.001 | 1.50 (1.28–1.76) | 24 | 96.0 | 0.035 | 6.75(0.88–51.67) |
| ER/ PR status c | |||||||||
| ER + | 136 | 62 | 45.6 | 112 | 82.4 | ||||
| ER - | 33 | 12 | 36.4 | 0.338 | 1.47 (0.67–3.22) | 25 | 75.8 | 0.386 | 1.49(0.60–3.71) |
| PR + | 103 | 49 | 47.6 | 88 | 85.4 | ||||
| PR - | 64 | 25 | 39.1 | 0.282 | 1.42 (0.75–2.67) | 48 | 75.0 | 0.092 | 1.96(0.89–4.30) |
| ER + PR + | 103 | 49 | 47.6 | 88 | 85.4 | ||||
| ER - PR - | 33 | 12 | 36.4 | 0.260 | 1.59(0.70–3.56) | 25 | 75.8 | 0.197 | 1.96(0.89–4.30) |
aTumor Size was available for 177 IDCs; bTumor Grades were available for 173 IDCs; cER and PR status was available for 169 and 167 IDCs only in our clinical databases. Membranous EpEx expression or loss of Membranous EpEx did not show significant correlation with any clinical or pathological parameters, hence the data are not shown in this Table. The p-value in boldface are statically significant.