Table 2. Association between REG4 expression and clinicopathologic parameters in colorectal cancer.
| REG4 expression | |||
| negative | positive | ||
| n (%) | 580 (73.1) | 213 (28.9) | p-value |
| Age. years | |||
| <65 | 245 (42.2) | 94 (44.1) | 0.686 |
| ≥65 | 335 (57.8) | 119 (55.9) | |
| Gender | |||
| Male | 313 (54.0) | 128 (60.1) | 0.124 |
| Female | 267 (46.0) | 85 (39.9) | |
| Dukes | |||
| A | 75 (12.9) | 44 (20.7) | 0.014 |
| B | 202 (34.8) | 73 (34.3) | |
| C | 164 (28.3) | 55 (25.8) | |
| D | 139 (24.0) | 41 (19.2) | |
| Grade (WHO) | |||
| 1 | 14 (2.4) | 13 (6.2) | 0.064 |
| 2 | 394 (68.3) | 150 (71.1) | |
| 3 | 150 (26.0) | 38 (18.0) | |
| 4 | 19 (3.3) | 10 (4.7) | |
| Missing | |||
| Location | |||
| Colon | 294 (50.7) | 116 (54.5) | 0.346 |
| Rectum | 286 (49.3) | 97 (45.5) | |
| Side | |||
| Right | 147 (25.3) | 70 (32.9) | 0.035 |
| Left | 433 (74.7) | 143 (67.1) | |
| Histology | |||
| Adenomatous | 539 (92.9) | 173 (81.6) | <0.0001 |
| Mucinous | 41 (7.1) | 39 (18.4) | |
Exact Pearson chi-square test for 2×2 tables and exact linear-by-linear association test for tables with ordered variables. Missing data excluded from analyses.