Table 1. Subject demographics.
Healthy Controls | Cystic Fibrosis | P value | |
Sex (Female:Male) | 11∶11 | 17∶24 | 0.5 |
Age (years) | 26 (25–32) | 28 (22–32) | 0.9 |
BMI (kg/metre2) | 24.6 (21.4–28.3) | 23.5 (20.5–25.8) | 0.3 |
FEV1 (Litres) | 4.1 (3.5–4.7) | 2.2 (1.4–2.5) | <0.001 |
FEV1% Predicted (%) | 110 (101–120) | 58 (37–75) | <0.001 |
FVC (Litres) | 4.9 (4.4–5.7) | 3.1 (2.6–4.1) | <0.001 |
FVC % Predicted (%) | 107 (95–112) | 76 (58–84) | <0.001 |
CFTR Genotype | |||
F508del Homozygotes | 20 | ||
F508del Heterozygotes | 18 | ||
Other mutations | 3 | ||
Sputum Microbiology * | |||
Pseudomonas aeruginosa | 36 | ||
Staphylococcus aureus | 12 | ||
Aspergillus fumigatus | 5 | ||
Haemophilus influenzae | 4 | ||
Stenotrophomonas maltophilia | 3 | ||
Chryseobacterium indologenes | 2 | ||
Scedosporium apiospermum | 2 | ||
Mycobacterium intracellulare | 1 | ||
Burkholderia gladioli | 1 | ||
Achromobacter xylosoxidans | 1 | ||
Methicillin resistant S. aureus | 1 |
Data presented as median (interquartile range).
*Summary data, subjects may have had more than one pathogen isolated in sputum, individual microbiological data available in Table S1 in File S2.