Table 2. Comparison of lymphocyte sub-sets between CF and healthy control subjects.

Lymphocyte Population (size gated, CD14−)	CF (n = 41)	Non-CF (n = 22)	P-Value
T-Cells (CD3+CD16−)	72.6 (68.1–79.6)	74.9 (67.9–79.0)	0.6
CD4+CD8−	65.2 (56.1–70.5)	65.1 (59.9–71.4)	0.6
CD8+CD4−	25.7 (21.1–32.5)	27.4 (22.7–32.8)	0.6
MAIT Cells (CD161+, TCR Va7.2+)	1.1 (0.4–1.9)	2.0 (1.4–3.1)	0.002
γ/δ T-cells (TCR γ/δ+)	10.4 (6.5–13.4)	6.4 (4.6–9.4)	0.012
CD4+CD8+	0.3 (0.2–1.0)	0.4 (0.3–1.7)	0.1
CD4−CD8−*	2.1 (0.9–3.3)	1.6 (1.1–2.3)	0.3
B-Cells (CD3−CD16−CD20+HLA-DR+)	9.5 (4.9–14.3)	4.8 (3.9–8.7)	0.1
Non-Resting (CD1c−)	64.6 (57.0–74.4)	71.6 (60.5–75.1)	0.5
Resting (CD1c+)	35.0 (24.8–43.	28.1 (25.0–38.3)	0.4
NK-Cells (CD3−)	9.5 (6.9–12.2)	13.1 (8.0–18.0)	0.013
CD16+CD56dim HLA-DR−	75.1 (61.0–86.7)	88.0 (84.7–92.6)	0.001
CD16−CD56+HLA-DR−	8.9 (6.1–13.2)	6.1 (4.5–9.1)	0.016
CD16−CD56+HLA-DR+	14.4 (5.1–24.1)	4.3 (2.7–9.2)	0.005
CD3+CD16+	2.2 (1.1–3.8)	1.8 (1.1–3.6)	0.7
Contaminants/Undefined	3.7 (3.0–5.2)	2.4 (1.9–3.9)	0.013

*After exclusion of MAIT and γ/δ T-cells. Values expressed as percentage of parent population, Median (interquartile range). Significance of between group differences determined by Mann-Whitney U test.