Table 2. Comparison of lymphocyte sub-sets between CF and healthy control subjects.
Lymphocyte Population (size gated, CD14−) | CF (n = 41) | Non-CF (n = 22) | P-Value |
T-Cells (CD3+CD16−) | 72.6 (68.1–79.6) | 74.9 (67.9–79.0) | 0.6 |
CD4+CD8− | 65.2 (56.1–70.5) | 65.1 (59.9–71.4) | 0.6 |
CD8+CD4− | 25.7 (21.1–32.5) | 27.4 (22.7–32.8) | 0.6 |
MAIT Cells (CD161+, TCR Va7.2+) | 1.1 (0.4–1.9) | 2.0 (1.4–3.1) | 0.002 |
γ/δ T-cells (TCR γ/δ+) | 10.4 (6.5–13.4) | 6.4 (4.6–9.4) | 0.012 |
CD4+CD8+ | 0.3 (0.2–1.0) | 0.4 (0.3–1.7) | 0.1 |
CD4−CD8−* | 2.1 (0.9–3.3) | 1.6 (1.1–2.3) | 0.3 |
B-Cells (CD3−CD16−CD20+HLA-DR+) | 9.5 (4.9–14.3) | 4.8 (3.9–8.7) | 0.1 |
Non-Resting (CD1c−) | 64.6 (57.0–74.4) | 71.6 (60.5–75.1) | 0.5 |
Resting (CD1c+) | 35.0 (24.8–43. | 28.1 (25.0–38.3) | 0.4 |
NK-Cells (CD3−) | 9.5 (6.9–12.2) | 13.1 (8.0–18.0) | 0.013 |
CD16+CD56dim HLA-DR− | 75.1 (61.0–86.7) | 88.0 (84.7–92.6) | 0.001 |
CD16−CD56+HLA-DR− | 8.9 (6.1–13.2) | 6.1 (4.5–9.1) | 0.016 |
CD16−CD56+HLA-DR+ | 14.4 (5.1–24.1) | 4.3 (2.7–9.2) | 0.005 |
CD3+CD16+ | 2.2 (1.1–3.8) | 1.8 (1.1–3.6) | 0.7 |
Contaminants/Undefined | 3.7 (3.0–5.2) | 2.4 (1.9–3.9) | 0.013 |
*After exclusion of MAIT and γ/δ T-cells. Values expressed as percentage of parent population, Median (interquartile range). Significance of between group differences determined by Mann-Whitney U test.