Figure 1. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.

Proliferation of antigen-stimulated spleen cells from mice immunized with the model antigen OVA alone or adjuvanted with the model cyclic di-nucleotide c-di-AMP or cGAMP was measured by ³H-thymidine incorporation. Spleen cells of the mock sample were taken from antigen and adjuvant free immunization control mice. The error bars represent the SEM of three independent experiments with five mice per group per experiment. Significant differences between select groups are indicated with * for p<0.05.