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. 2014 Sep 3;18(5):488. doi: 10.1186/s13054-014-0488-y

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© Fenhammar et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Changes in renal artery blood flow (RBF) (A), laser Doppler changes in renal cortex (LD Cortex) (B), laser Doppler changes in renal medulla (LD Medulla) (C), renal vascular resistance (RVR) (D), lactate/pyruvate ratio in cortex (L/P Cortex) (E), and lactate/pyruvate ratio in medulla (L/P Medulla) (F) in response to sepsis and treatment with either the selective TLR4 inhibitor TAK-242 (n = 7) or vehicle (n = 7). Data are expressed as mean and 95% confidence interval. Asterisk indicates a significant difference between TAK-242 and control in response to sepsis. Analysis of variance (ANOVA) repeated measures from 12 to 36 hours.