Table 4.
Logistic regression models for combined death and nonfatal events, stratified by presence of CHD at baseline, comparing eGFR with both the MDRD and CKD-EPI equations
| Free of CHD | CHD | |||
|---|---|---|---|---|
| RR | 95% CI | RR | 95% CI | |
| Combined events/Total at risk | 34/469 | 66/320 | ||
| eGFR with MDRD | ||||
| Sex, male | 1.32 | 0.61; 2.85 | 1.16 | 0.60; 2.24 |
| Age, 8 years | 1.53 | 1.03; 2.32 | 1.71 | 1.24; 2.35 |
| eGFR Quartile 1*, 69 ml/min/ | 0.78 | 0.21; 2.86 | 1.85 | 0.75; 4.53 |
| eGFR Quartile 3*, 115 ml/min/ | 2.25 | 0.94; 6.88 | 2.28 | 0.96; 5.42 |
| eGFR Quartile 4*, 163 ml/min/ | 4.00 | 1.34; 11.9 | 2.72 | 1.08; 6.81 |
| Hypertension, yes/no | 1.34 | 0.62; 2.89 | 0.83 | 0.46; 1.49 |
| Body mass index, 4 kg/m2 | 1.06 | 0.71; 1.57 | 1.23 | 0.91; 1.64 |
| Current vs never smoking | 1.37 | 0.52; 3.57 | 1.06 | 0.45; 2.50 |
| Former vs never smoking | 2.85 | 1.08; 7.56 | 1.06 | 0.45; 2.49 |
| eGFR with CKD-EPI | ||||
| Sex, male | 1.31 | 0.61; 2.80 | 0.85 | 0.44; 1.62 |
| Age, 8 years | 1.78 | 1.13; 2.85 | 1.73 | 1.22; 2.48 |
| eGFR Quartile 2*, 94 ml/min/1.73 | 2.07 | 0.64; 6.68 | 1.05 | 0.48; 2.31 |
| eGFR Quartile 3*, 104 ml/min/1.73 | 2.84 | 0.87; 9.22 | 1.45 | 0.58; 3.11 |
| eGFR Quartile 4*, 118 ml/min/1.73 | 6.08Ť | 1.68; 22.0 | 1.36 | 0.55; 3.34 |
| Hypertension, yes/no | 1.30 | 0.61; 2.78 | 0.83 | 0.47; 1.48 |
| Body mass index, 4 kg/m2 | 1.02 | 0.69; 1.53 | 1.20 | 0.90; 1.60 |
| Current vs never smoking | 1.30 | 0.51; 3.37 | 0.98 | 0.42; 2.29 |
| Former vs never smoking | 2.74 | 1.05; 7.18 | 0.98 | 0.42; 2.28 |
*Referent is expressed for quartile 2 in the upper, for quartile 1 (70 ml/min/) in the lower model.
Number of subjects in the group without and with CHD, respectively: 151/181 hypertensives; 164/144 current and 57/121 former smokers. CHD, coronary heart disease Ť p trend 0.048.