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. 2014 Sep 16;11:162. doi: 10.1186/s12974-014-0162-y

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© Jayaraman et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Low testosterone and high-fat diet increase proinflammatory cytokines TNFα and IL-1b mRNA and decrease myelin sheath marker P0 mRNA in sciatic nerve. (A) Quantitative real-time PCR data show the mean (±SEM) expression levels compared to the Sham control group for TNFα mRNA. (B) Quantitative real-time PCR data show the mean (±SEM) expression levels compared to the Sham control group for IL-1β mRNA. (C) Quantitative real-time PCR data show the mean (±SEM) expression levels compared to the Sham control group for P0 mRNA. All data are normalized with corresponding β-actin values. Statistical significance is based on ANOVA followed by Bonferroni. * P ≤0.05 between diet groups; ** P ≤0.05 between hormone groups; N ≥6.