Table 1.
Reported factors involved in fibrogenesis of NASH.
| Factors | Reference No. |
|---|---|
| Apoptosis of hepatocytes due to the deposition of TG | [41] |
| due to activated death receptors | [65] |
| Insulin resistance | [69,72,73,74,75,76,77,78] |
| Oxidative stress | [68,69,73,75,79] |
| Pro-inflammatory cytokines | [67,68,69,70,71,72,73,74,75,76,77,78,80,81,82,83] |
| Adipokines including leptin | [70,72,73,74,80] |
| Innate immune responses including TLRs | [73,74,84,85,86,87,88,89,90] |
| Connective tissue growth factor due to high glucose level | [67] |
| due to hyperinsulinemia | [67] |
| Liver fatty acid binding protein (L-Fabp) | [91] |
| Farnesoid X receptor (FXR) | [73,79] |
| Peroxisome proliferator-activated receptors (PPARγ) | [47,74,77,92] |
| MCP-1, CCR2 | [93] |
| Bone-marrow-derived macrophages (Ly6C) | [93,94] |
| Hepatic stem/progenitor cells (HPCs) | [95,96,97,98,99] |