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. 2014 Jun 27;6(3):1220–1255. doi: 10.3390/cancers6031220

Table 2.

Risk Factors involved in Carcinogenesis of NASH.

Risk Factor Reference No.
Age [116]
Obesity [3,4,5,79]
Type 2 diabetes mellitus [3,4,5]
Fibrosis [8,121,125,126]
Daily alcohol consumption [116]
Lipid-modifying enzymes to produce MUFA* [127]
Insulin resistance [4]
Hypoadiponectinemia [4,79]
Hyperinsulinemia [79,128]
Oxidative stress, release of ROS [4]
Inhibition of NF-κB [4]
Absence of JNK1 [4]
TLRs [91]

*MUFA: monounsaturated fatty acids.