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Interaction of ST with PP2A. Polyomavirus ST competes with the B subunit of PP2A for binding to the structural A subunit and the catalytic C subunit. In SV40, this interaction between ST and PP2A Aα leads to cell transformation. Although the interaction of MCPyV ST with PP2A Aα may not be necessary for transformation, interaction with PP2A Aβ or the related PP4C may play a role.
