Table 2.

Connection between lipoxygenase activity and NF-κB activity in specific diseases.

Disease	Observations	Ref.
Asthma	Ectopic expression of 15-LOX induces NF-κB mediated reporter gene expression in epithelial cells.	[45]
Cardiovascular diseases	Increased levels of 5-LOX metabolites in patients with atherosclerosis.	[46]
	The 15-LOX metabolite 15-HETE activates the NF-κB pathway and stimulates 15-LOX expression in a positive feedback loop.	[47]
Rheumatoid Arthritis	The 15-LOX metabolite 15-HETE increases IκBα degradation and activation of the NF-κB pathway.	[48]
Cancer	The 5-LOX metabolite LTB4 is capable of activating the transcription factor NF-κB in cancer cells	[49]