Table 2.
Urinary excretion of trimethylamine and trimethylamine N -oxide by the proband and family members under normal dietary conditions and after 300g marine fish meal
| |
Normal dietary conditions |
300g marine fish meal |
||||||
|---|---|---|---|---|---|---|---|---|
| TMA (mmol/mol Crn) | TMAO (mmol/mol Crn) | TMA/TMAO ratio | Amount of total TMA excreted as TMAO (%) | TMA (mmol/mol Crn) | TMAO (mmol/mol Crn) | TMA/TMAO ratio | Amount of total TMA excreted as TMAO (%) | |
| Mother |
104 |
5960 |
0.02 |
98.3 |
480 |
19140 |
0.02 |
97 |
| Father |
70 |
1820 |
0.04 |
96.3 |
640 |
14000 |
0.04 |
95.6 |
| Proband |
117 |
48 |
2.4 |
29.0 |
738 |
178 |
4.1 |
19.4 |
| Brother1 |
20 |
600 |
0.03 |
97.0 |
225 |
5420 |
0.04 |
99.0 |
| Brother2 | 35 | 910 | 0.04 | 96 | 320 | 12220 | 0.02 | 97.0 |
Normal ratio: TMA/TMAO = 0.0025 to 0.055 (>85% TMAO).
Affected ratio: TMA/TMAO >0.2 (<20% TMAO).
Abbreviations: Crn creatine, TMA trimethylamine, TMAO trimethylamine N-oxide.