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. 2014 Oct 7;107(7):1675–1685. doi: 10.1016/j.bpj.2014.08.008

Figure 1.

Figure 1

(A) The initial structures of the WT cTn complex were built up based on Takeda et al.’s (11) crystal structure and Howarth et al.’s (21) NMR structure. The inhibitory-peptide region (residues 138–147) of cTnI and the C-terminus (residues 280–285) of cTnT were modeled using Rosetta. cTnC (1–161) is shown in blue, cTnI (residues 1–172) is in red, and cTnT (residues 236–285) is in gold. Asterisks indicate the key positions in cTnI. (B) Close-up of the region around sites 23/24 of cTnI in the cTnI-S23D/S24D cTn model. The substitutions result in close apposition of negative charges on D23/D24 of cTnI with E32 and D33 between the A- and B-helices of cTnC. To see this figure in color, go online.