Table 1. SAR of 2-Pyridylpyrimidine Analogues.

^aValues derived from a 11-point dose–response curve performed in triplicate. The number of replicates range from 1 to 4 as indicated, with standard deviation reported in parentheses where available.

^bHEK293 cells expressing human or mouse GPR39.

^cPredicted hepatic clearance based on intrinsic clearance in rat liver microsomes. Scaling factors for Cl(int) → Cl(h): 45 mg of microsomal protein/g of liver; 40 g of liver/kg of body weight; and 55 mL of portal blood flow/min/kg. N.D. = not determined.