Figure 5.

A proposed model of Aβ oligomer function on apoptotic BAK pore formation. (A) Normal apoptotic pathway; tBID induces conformational change of BAK, inducing membrane insertion followed by oligomerization, which results in apoptotic BAK pores. (B) Aβ oligomers hijack the apoptotic pathway by inducing BAK conformational change such that apoptotic BAK pores are formed in the absence of the death signal. To see this figure in color, go online.