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. 2014 Oct 8;5:5070. doi: 10.1038/ncomms6070

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(a) Mitotic metaphase with one chromosome highlighted in the upper corner. Note the multiple sites of microtubule attachment. (b) Mitotic metaphase with chromosomes labelled with an antibody directed against CENH3, which localizes in two parallel lines along each chromosome. (c–e) Polar view of meiotic metaphase I with one bivalent highlighted. The same cell is viewed in an upper focal plane (c), a medium focal plane (d) and a lower focal plane (e). (f) Chromosomes at meiotic metaphase I labelled with an antibody directed against CENH3, which localizes in distinct patches along both sides of each bivalent. (g–h) Metaphase II. Upper (g) and lower (h) focal planes of the same cell. (i) Scheme of orientation of metaphase chromosomes marked with * in g,h representing the five chromatids attached to microtubules from each spindle pole and an overlay showing the bipolar orientation. (a,c–e,g,h) Chromosomes in red, microtubules in green. (b,f) Chromosomes in blue, CENH3 in magenta. Size bars correspond to 5 μm.