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Integral microRNA transcription regulator networks control epithelial-mesenchymal plasticity. MicroRNAs such as miR-34, miR-200 and let-7 promote the EMT or MET by interacting with certain transcription factors and epigenetic regulators10,12,51,99,128–130. Reciprocal negative feedback loops appear to be a common feature that regulates the bi-stable residence of cells in two distinct states.
